Dementia or cognitive dysfunction is the common problem in today’s fast life. Age, stress and emotions are the condition that may lead to memory loss. In traditional system of Ayurvedic medicine, numerous herbs possessing saponins have been used to treat cognitive disorder. Taverniera cuneifolia (Fabaceae) is the rich source of saponins. Two doses (100 and 200 mg/kg, p.o.) of n-butanolic fraction Taverniera cuneifolia extract (TCE) were administered for 7 successive days in separate group of animals. Furthermore, on the 7th day scopolamine (0.4 mg/kg, p.o.) administered to as cognitive deficit. The series of established neuropharmacological tests including elevated plus maze and passive avoidance paradigm were studied on 7th and 8th day. Baclofen induced hypothermia and measurement of acetylcholinestrase (AChE) activity were also carried out. TCE significantly improved learning and memory both in absence and presence of cognitive deficit. Also reversed the baclofen induced hypothermia. The mechanism by which TCE exerts nootropic activity was decreased AChE activity and inhibition of GABAB receptor. With the above data, we can conclude that Taverniera cuneifolia extract shows potent nootropic activity both in absence and presence of cognitive deficit.
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